Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis

Launched by INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE GIRONA DR. JOSEP TRUETA · May 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of inhaling a saline solution before a specific breathing exercise called the ELTGOL technique in adults with bronchiectasis. Bronchiectasis is a long-lasting lung condition that makes it hard for the body to clear mucus, leading to infections and breathing difficulties. The researchers want to see if inhaling this saline solution can make the mucus thinner and easier to remove, which could improve the effectiveness of the physiotherapy treatment.

To join the study, participants need to be adults aged 65 to 74 with a confirmed diagnosis of bronchiectasis and a history of mucus production. They should not have had any serious flare-ups in the past month and must be able to perform the breathing exercises. If they qualify, participants will receive saline inhalation therapy and practice the ELTGOL technique. This trial is currently recruiting, and if the results are positive, this approach could significantly improve the management of bronchiectasis for many patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients with bronchiectasis confirmed by high resolution computed tomography
• • No exacerbations in the previous month
• • Chronic mucopurulent and purulent sputum
• • ≥10ml daily expectoration
• • At least one exacerbation in the previous year
• • (Forced expiratory volume the 1st second) FEV1 ≥30% after bronchodilation
• • Sign the informed consent
• Exclusion Criteria:
• • Current smokers or a smoking history of ≥20 p-y
• • Asthma, allergic bronchopulmonary aspergillosis or Cystic Fibrosis
• • Pregnant or lactating women
• • Following mucoactive treatment in the previous month
• • Inability to perform ELTGOL, spirometry or to attend visits
• • Practicing pulmonary rehabilitation in the previous 6 months
• • Change of treatment the previous month
• • Uncontrolled hypertension

Trial Officials