An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients with Glioma

Launched by MAYO CLINIC · May 31, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a new type of imaging called gallium-68 (Ga-68) PSMA-11 PET/CT scan to help doctors better understand whether a patient’s glioma (a type of brain tumor) has come back after treatment or is getting worse. After initial treatment, it can be hard for doctors to tell if changes seen on regular imaging scans are due to the tumor returning or just the effects of treatment. This study aims to see if this new scan can provide clearer information, helping doctors make better decisions for patients with WHO Grade 3 or Grade 4 gliomas.

To be eligible for this trial, participants need to be at least 18 years old, have a history of Grade 3 or 4 glioma that has been treated, and have MRI results suggesting the tumor may be returning. Participants should be planning to have surgery to remove the tumor and must be able to give informed consent. During the trial, participants will undergo the new imaging scan, which combines two types of imaging to provide detailed pictures of the brain. This might help improve how doctors detect and manage gliomas in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years.
• • History of World Health Organization (WHO) grade III or IV infiltrating glioma previously treated with first-line chemoradiotherapy.
• • MRI findings compatible with contrast-enhancing recurrent infiltrating glioma.
• • Planned craniotomy for resection of suspected disease recurrence.
• • Willing to sign release of information for any radiation and/or follow-up records.
• • Ability to provide informed written consent.
• • Ability to provide tissue for mandatory correlative research component.
• Exclusion Criteria:
• • Previous treatment with antiangiogenic therapy (e.g. bevacizumab).
• • Unable to undergo a PSMA PET/CT scan (e.g. body habitus, claustrophobia).
• * Any of the following:
• • Pregnant women
• • Nursing women
• • Men or women of childbearing potential unwilling to employ adequate contraception

Trial Officials