Trials
Search / Trial NCT06444477

Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Jun 3, 2024

Trial Information

Current as of February 12, 2025

Not yet recruiting

Keywords

Proteomics Mortality Side Effects Multicenter Retrospective

ClinConnect Summary

Autoimmune thrombocytopenia, also known as immune thrombocytopenic purpura (ITP), is a rare autoimmune disease characterized by platelet destruction and impaired production, posing a life-threatening risk due to bleeding complications. The pathophysiology of ITP involves complex mechanisms, including both defective platelet production and auto-reactivity of B and T lymphocytes leading to the production of autoantibodies against platelets, found in 35 to 55% of cases. Additionally, in the context of neoplasia, some patients may develop varying degrees of thrombocytopenia, exacerbating morbid...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adult patients with a definite diagnosis of both ITP and cancer;
  • Synchronous diagnosis of ITP and cancer;
  • Onset of ITP occurring 6 months before or after the diagnosis of cancer.
  • Exclusion Criteria:
  • None

Trial Officials

Etienne RIVIERE, MD

Principal Investigator

University Hospital, Bordeaux

About University Hospital, Bordeaux

The University Hospital of Bordeaux is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the institution integrates cutting-edge scientific inquiry with patient care, fostering an environment that encourages collaboration among multidisciplinary teams. With a commitment to improving treatment outcomes and enhancing patient safety, the University Hospital of Bordeaux plays a pivotal role in the development of new therapies and medical technologies, contributing significantly to the global medical community.

Locations

Toulouse, , France

Bondy, , France

Clermont Ferrand, , France

Créteil, , France

Le Kremlin Bicêtre, , France

Lille, , France

Lyon, , France

Marseille, , France

Montpellier, , France

Nancy, , France

Nantes, , France

Orléans, , France

Orléans, , France

Paris, , France

Paris, , France

Paris, , France

Pessac, , France

Poitiers, , France

Strasbourg, , France

Tours, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0