Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer
Launched by UNIVERSITY HOSPITAL, BORDEAUX · Jun 3, 2024
Trial Information
Current as of February 12, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Autoimmune thrombocytopenia, also known as immune thrombocytopenic purpura (ITP), is a rare autoimmune disease characterized by platelet destruction and impaired production, posing a life-threatening risk due to bleeding complications. The pathophysiology of ITP involves complex mechanisms, including both defective platelet production and auto-reactivity of B and T lymphocytes leading to the production of autoantibodies against platelets, found in 35 to 55% of cases. Additionally, in the context of neoplasia, some patients may develop varying degrees of thrombocytopenia, exacerbating morbid...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult patients with a definite diagnosis of both ITP and cancer;
- • Synchronous diagnosis of ITP and cancer;
- • Onset of ITP occurring 6 months before or after the diagnosis of cancer.
- Exclusion Criteria:
- • None
Trial Officials
Etienne RIVIERE, MD
Principal Investigator
University Hospital, Bordeaux
About University Hospital, Bordeaux
The University Hospital of Bordeaux is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the institution integrates cutting-edge scientific inquiry with patient care, fostering an environment that encourages collaboration among multidisciplinary teams. With a commitment to improving treatment outcomes and enhancing patient safety, the University Hospital of Bordeaux plays a pivotal role in the development of new therapies and medical technologies, contributing significantly to the global medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Toulouse, , France
Bondy, , France
Clermont Ferrand, , France
Créteil, , France
Le Kremlin Bicêtre, , France
Lille, , France
Lyon, , France
Marseille, , France
Montpellier, , France
Nancy, , France
Nantes, , France
Orléans, , France
Orléans, , France
Paris, , France
Paris, , France
Paris, , France
Pessac, , France
Poitiers, , France
Strasbourg, , France
Tours, , France
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0