Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.

Launched by HASSELT UNIVERSITY · May 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the tiny particles released from fat cells, known as extracellular vesicles (EVs), in people with obesity. The researchers want to understand how these particles differ between individuals who are lean and those who are obese, and how they may relate to factors like sex, insulin sensitivity (how well the body uses insulin), and the blood-brain barrier (a protective layer for the brain). This research is important because obesity can lead to serious health issues such as type 2 diabetes and heart disease, and understanding these connections could help improve treatments.

To participate in this trial, you need to be a Caucasian adult aged 18 to 65 with either obesity (a body mass index of at least 35) and scheduled for your first weight-loss surgery, or lean (a body mass index between 18 and 24.9) and scheduled for abdominal surgery, if you're female. Participants will need to be able to read and understand the informed consent in Dutch. Unfortunately, those with certain health problems like cardiovascular disease, lung disease, or cancer cannot join. If you qualify and decide to participate, you will help researchers gather valuable information that could lead to better understanding and treatments for obesity-related diseases.

Gender

ALL

Eligibility criteria

• Individuals with obesity - Inclusion Criteria:
• • Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery.
• • Final male/female ratio of this study is 1:1
• • Minimal knowledge of Dutch to read and understand the informed consent.
• Individuals with obesity - Exclusion Criteria:
• • Smoking and/or drug abuse
• • Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
• • Lung and/or kidney diseases
• • Brain and/or nerve diseases
• • Malignant diseases (e.g. cancer)
• • Individuals without obesity (lean) - inclusion criteria
• • Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery
• • Female only
• • Minimal knowledge of Dutch to read and understand the informed consent.
• • Individuals without obesity (lean) - exclusion criteria
• • Smoking and/or drug abuse
• • Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
• • Lung and/or kidney diseases
• • Brain and/or nerve diseases
• • Endocrine diseases like type 2 diabetes
• • Malignant diseases (e.g. cancer)