Effects of Mulligan Mobilization With Movement as Compared to Kaltenborn Joint Mobilization in the Management of Knee Osteoarthritis
Launched by FOUNDATION UNIVERSITY ISLAMABAD · Jun 5, 2024
Trial Information
Current as of September 16, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This study is a randomized trial comparing two physical-therapy approaches for knee osteoarthritis: Mulligan mobilization with movement (MWM) and Kaltenborn joint mobilization. Both groups will also receive a heating pad and a gentle electrical nerve stimulation (TENS) to help with pain, plus a resistance exercise program. The researchers want to know which method better reduces knee pain and improves movement, daily function, and walking ability, with outcomes assessed over about two weeks.
Who can participate? Adults aged 40–70 with knee osteoarthritis for at least 3 months, whose knee pain is not more than 8 out of 10 and who have knee X‑rays showing grade III OA or less. They must be referred from a rehabilitation department and not have serious health problems, recent knee trauma or surgery, nerve-related leg issues, or recent knee injections. The study is taking place at Foundation University Islamabad in Pakistan and is currently inviting eligible people to join, aiming to enroll about 40 participants. Outcomes measured over the 2‑week period include knee pain (on a 0–100 scale), knee function (KOOS), knee range of motion, stride length, walking speed, leg strength, and how long it takes to perform five sit-to-stand movements.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Individuals aged 40-70 years (Osama et al, 2022)
- • Having KOA history of no less than 3 months
- • Knee pain less than 8/10 on numeric pain rating scale (NPRS).
- • Radiological evidence of grade III or less on Kellgren classification
- • Patients referred from rehab department
- Exclusion Criteria:
- • Those with signs of serious pathology, such as malignancy, inflammatory disorder or infection.
- • History of trauma or fractures in lower extremity.
- • Signs of lumbar radiculopathy or myelopathy.
- • History of knee surgery or replacement.
- • Receiving intra-articular steroid therapy in the preceding two months.
About Foundation University Islamabad
Foundation University Islamabad (FUI) is a prominent educational institution dedicated to advancing research and innovation in various fields, including clinical sciences. With a commitment to excellence in education and healthcare, FUI fosters a collaborative environment that encourages multidisciplinary research initiatives. The university actively engages in clinical trials aimed at improving patient outcomes and contributing valuable insights to the medical community. Through its state-of-the-art facilities and a team of experienced professionals, Foundation University Islamabad strives to uphold the highest ethical standards in clinical research, ensuring the integrity and reliability of its findings.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Islamabad, Pakistan
Patients applied
Trial Officials
Shanza Fatima, DPT
Principal Investigator
Foundation University Islamabad
Muhammad Osama, PHD*
Principal Investigator
Foundation University Islamabad
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported