Evaluating the Impact of a Virtually Supervised Exercise Intervention and Group Counseling on Inflammation and the Microbiome of Smokers at High Risk for Lung Cancer, BE FIT Trial

Launched by OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER · May 31, 2024

Keywords

ClinConnect Summary

The BE FIT Trial is a clinical study looking at how a supervised exercise program, combined with group counseling, can affect inflammation and the gut bacteria of smokers who are at high risk for lung cancer. The researchers believe that exercise can help reduce the risk of developing lung cancer and improve overall health by positively influencing inflammation and the gut microbiome, which is the community of bacteria living in our digestive system. The counseling sessions aim to encourage participants to stick with their exercise routine by helping them take control of their health choices.

To participate, individuals must be between 50 and 77 years old, have a history of smoking (at least 20 pack-years), and currently engage in little to no moderate exercise each week. They should also be in good health without serious heart or breathing problems. Participants will need to agree to the study and follow the exercise and counseling guidelines. This trial is currently recruiting and welcomes all genders. By joining, participants may not only contribute to important research but also potentially improve their health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 50-77 years of age
• • Current or former smoker with 20-pack year smoking history and within the last 15 years
• • Fewer than 60 minutes of participation in moderate intensity physical activity each week
• • All participants must be free of severe heart, respiratory (e.g. chronic obstructive pulmonary disease \[COPD\]), or systemic disease that would make moderate intensity exercise participation unsafe
• • Willing to sign an informed consent
• Exclusion Criteria:
• • Person is on a regimen of the following medications: immunosuppressants, bisphosphonates, steroids, anticoagulants, warfarin, apixaban, probiotics
• • Person undergoing treatment for cancer in any form
• • Person plans to enter smoking cessation or change status

Trial Officials