Accelerated Intermittent Theta-burst Stimulation to Modify Cognitive Function and Balance in Dementia and Memory Loss

Launched by MCMASTER UNIVERSITY · May 31, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring a treatment called repetitive Transcranial Magnetic Stimulation (rTMS) to see if it can improve balance and cognitive function in people with dementia or memory loss. The study will compare two different locations in the brain where rTMS is applied to find out which one is more effective for helping with balance. This is important because improving balance can help prevent falls, which are a major concern for older adults and can lead to serious injuries and increased healthcare costs.

To be eligible for the trial, participants should be at least 50 years old and have a diagnosis of dementia or memory loss. They need to have some ability to communicate and understand instructions in English, either on their own or with the help of a caregiver. Participants should also be able to walk or stand with some support if needed. However, there are some health conditions, like having a pacemaker or a history of seizures, that would prevent someone from participating. If you join the study, you'll be part of important research that could help improve care for individuals with dementia in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Individuals must be diagnosed with Dementia and/or memory loss by a clinician.
• • 2. Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score ranging between 10-27 on the Mini-Mental State Exam (Wu et al., 2022).
• • 3. Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English or have a caregiver present who can translate and be presented during all study sessions.
• • 4. Individuals must be able to walk or stand with or without personnel or assistive devices.
• • 5. Individuals must be greater than or equal to 50 years of age.
• Exclusion Criteria:
• • 1. Contraindications to rTMS; presence of a pacemaker, metal/electrical/magnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, are taking any prescription medications that increase the risk of seizure.