Effects of RCT on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in CKD Patients With AP

Launched by POSTGRADUATE INSTITUTE OF DENTAL SCIENCES ROHTAK · May 31, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how non-surgical root canal treatment affects healing and inflammation in patients with chronic kidney disease (CKD) who also have a dental condition called apical periodontitis, which is an infection at the tip of the tooth root. The goal is to see if this treatment helps improve not only dental health but also kidney function and inflammation markers in the body.

To participate in this study, you must be at least 18 years old, have chronic kidney disease (stages 1 to 5), and have at least 12 natural teeth (not including wisdom teeth). If you have additional health issues like diabetes or are pregnant, you won't be eligible. Participants will receive the root canal treatment and may have their healing and kidney functions monitored over time. This study aims to gather important information that could help improve dental care for patients with kidney disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1- Known patient of Chronic Kidney Disease \[CKD Stages 1,2,3,4,5 with mature permanent teeth.
• • 2. Age18year or older . 3. ≥ to 12 natural teeth (excluding 3rd molars) 4 The periapical index (PAI) was used to evaluate the periapical status patients with PAI ≥3 are included in the study.
• Exclusion Criteria:
• • 1. Patients having systemic disorders other than chronic kidney disease (e.g HIV; Diabetes mellitus; Coronary heart disease; no history of secondary hyperparathyroidism)
• • 2. Patients with periodontitis , pocket depth and CAL\>5mm( stage 3 ,4) will be excluded.
• • 3. Pregnancy; lactation \& contraceptives.
• • 4. Patients taking antibiotics, statins, corticosteroids and aspirin which can affect the level of inflammatory markers in past one month.

Trial Officials