Brain Blood Flow Responses During Exercise: Younger Cohort

Launched by UNIVERSITY OF WISCONSIN, MADISON · May 31, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how blood flow in the brain changes during exercise. Researchers will use a special imaging technique called magnetic resonance imaging (MRI) to measure this blood flow while participants engage in aerobic activities like running on a treadmill or using a stationary bike. The goal is to understand how exercise affects brain circulation in healthy young adults.

To participate in this study, you need to be a healthy man or woman between the ages of 20 and 40, and you should regularly do aerobic exercise at least three times a week for at least 30 minutes. You should also be familiar with using cardiovascular exercise equipment. If you meet these criteria, the study will involve some exercise while being monitored with MRI to see how your brain responds. It’s important to note that participants will not be eligible if they have certain medical conditions, a high body mass index, or other specific health issues. This trial is currently recruiting participants, and it offers a unique opportunity to contribute to our understanding of brain health during exercise.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy men or women between the ages of 20-40 years old
• • Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes
• • Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper)
• Exclusion Criteria:
• • Outside of specified age range
• • Do not have experience using cardiovascular exercise equipment
• • Do not meet the physical activity criteria
• • Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes
• • have a body mass index ≥35 kg/m2
• • are ≥ 71 inches (180 cm) in height
• • have any contraindications to MRI
• • currently use or have a history of use of tobacco or illegal substances
• • have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded)
• • vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent)
• • if the desired moderate/vigorous exercise intensity corresponds to \> 350 watts on the stepper device

Trial Officials