Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis

Launched by ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE · Jun 5, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to identify new markers that can help predict which patients with sepsis might develop more severe complications, specifically septic shock. Sepsis is a serious condition that can happen when the body has a severe response to an infection. The researchers will compare genetic markers in patients who have sepsis but do not progress to septic shock with those who do, to see if they can find indicators that help determine the risk of worsening illness.

To be eligible for this trial, participants need to be male, between the ages of 45 and 75, and undergoing major surgery related to esophageal or digestive cancer. They should also have symptoms of bacterial sepsis after surgery. Unfortunately, women and patients outside this age range, as well as those with certain other health conditions, cannot participate. If someone joins the study, they will help researchers gather important data that could lead to better treatments for sepsis in the future.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male patients,
• • Patients between 45 and 75 years of age,
• • Patients undergoing major esophageal or digestive carcinological surgery,
• • Patients with post-operative gram-negative bacterial sepsis (proven or suspected in the context of organ failure).
• Exclusion Criteria:
• • patients under 45 and aged 76 and over,
• • female patients,
• • non-carcinological or minor surgery,
• • non-esophageal or non-digestive surgery,
• • Gram-positive bacterial or fungal infections in the absence of associated BGN,
• • patients with hematological cancer,
• • immunocompromised patients,
• • septic surgery (surgical site infection),
• • patients expressing opposition to data collection and analysis (clinical and/or biological) within the regulatory framework of the study,
• • patients under guardianship or curatorship,
• • patients not affiliated to a social security system or equivalent in France,
• • patients deprived of their liberty.

Trial Officials