Efficacy of New Post Kasai ILBS Protocol in Biliary Atresia.

Launched by INSTITUTE OF LIVER AND BILIARY SCIENCES, INDIA · Jun 3, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment approach for babies with biliary atresia, a serious liver condition that affects how bile drains from the liver. The aim is to see if a new protocol using corticosteroids after surgery (called the Kasai procedure) can improve bile flow and reduce bilirubin levels, which are important for liver health. Previous studies have shown mixed results, but some researchers believe that a tailored use of steroids might help more patients keep their liver function longer and avoid needing a liver transplant.

To participate in this trial, patients must have undergone the Kasai procedure at a specific hospital and meet certain criteria, such as not having major surgical complications. The trial is currently recruiting participants of all ages and genders. Those who join can expect to receive close monitoring and follow-up care to see how well this new treatment works. This study is important because it could lead to better outcomes for children with biliary atresia, helping them live healthier lives.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Post Kasai Biliary atresia operated at ILBS with retrospective historical cohort (Jan 2015 to Dec 2017) and retrospective + prospective cohort with new protocol (Jan 2018 till June 2024).
• Exclusion Criteria:
• • 1. Subjects having major surgical complications
• • 2. Defaulters or Patient not following protocol/not giving consent
• • 3. Biliary atresia splenic malformation