Cancer Loyalty Card Study 2 (CLOCS-2)

Launched by IMPERIAL COLLEGE LONDON · Jun 3, 2024

Keywords

ClinConnect Summary

The Cancer Loyalty Card Study 2 (CLOCS-2) is a research trial focused on improving early diagnosis of certain types of cancer, including pancreatic, colon, and ovarian cancers, among others. The study aims to understand how often people purchase over-the-counter medications and products for vague symptoms that may indicate cancer. By gathering this information, researchers hope to identify potential signs of cancer earlier and encourage people to seek medical help sooner.

To participate in CLOCS-2, you must be at least 18 years old. You can join as a "case" if you have been diagnosed with one of the targeted cancers within the last two years and have a loyalty card from a participating retailer. Alternatively, you can join as a "control" if you have not been diagnosed with any of these cancers but also have a loyalty card. Participants will provide information about their purchases and symptoms, which could help improve cancer diagnosis and treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria (ALL):
• • Individuals aged \>18 years of age
• • Individuals must be residing in the United Kingdom at the time of giving informed consent
• • Individuals must be registered with an NHS GP Practice
• • Individuals must meet the criteria of ONE of the groups. For example, to be eligible for Group 1 (Cases), individuals must have been diagnosed with one of the following cancer types in the last 24 months: Bladder, colorectal (bowel), endometrial, liver, oesophageal, ovarian, pancreatic, stomach (gastric), uterine, or vulval; whereas for Group 2 (Controls), individuals must not have received a cancer diagnosis of any type in the last 6 years (except where the diagnosis was of non-melanoma skin cancer).
• • Individuals must be a primary registered cardholder\* of one of the loyalty cards listed below, and consent to share their loyalty card data with the study team
• • Tesco Clubcard
• • Boots Advantage Card
• • Provision of written informed consent
• • Willing and able to comply with all required study activities
• • The primary registered card holder, i.e., the person who is named on the loyalty card account, must also enrol into the study, if someone other than the registered primary card holder from the same household, wants to take part in the study.
• Exclusion Criteria (ALL):
• • Individuals under the age of 18 years
• • Non-UK residents, at the time of giving informed consent
• • Individuals without an eligible loyalty card, or who have no one in their household who has an eligible loyalty card
• • Individuals who are not the primary registered cardholder in their household and where the primary registered loyalty card holder is not willing to join the study, and/or where the primary registered cardholder does not make purchases for or on behalf of the individual
• Exclusion Criteria (CASES):
• • Individuals will not be able to join as a case if:
• • they have been diagnosed with an eligible cancer type more than 24 months ago (except where the diagnosis was non-melanoma skin cancer).
• • they have received an ineligible cancer diagnosis within the last 6 years except where the diagnosis was non-melanoma skin cancer).
• Exclusion Criteria (Controls):
• • Individuals will not be able to join as a control (Group 2) if:
• • o they have received any cancer diagnosis in the last six years (except where the diagnosis was non-melanoma skin cancer).