Manipulating E-Cigarette Nicotine to Promote Public Health

Launched by OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER · Jun 3, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how different types of nicotine in e-cigarettes (ECs) can affect public health, especially in relation to addiction and health risks. Researchers want to understand how the strength and form of nicotine influence how people use e-cigarettes and how their bodies process nicotine. This study could help identify the best nicotine levels in e-cigarette products, which may lead to safer options for users.

To participate in this trial, you must be between 21 and 65 years old. You could be eligible if you are a young adult who has been using e-cigarettes exclusively for at least three months or if you are an older adult who smokes cigarettes regularly and is interested in trying e-cigarettes. Participants will need to avoid all nicotine and tobacco products for at least 12 hours before visits. It's important to note that pregnant or breastfeeding individuals and those with certain health conditions may not qualify. Overall, participants will contribute to valuable research that aims to promote better health outcomes related to e-cigarette use.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Current exclusive young adult EC user for at least the past 3 months (confirmed by cotinine testing strip) between 21-24 years old with no/minimal history of smoking cigarettes (≤ 10 cigarettes in entire life)
• • Current older adult smoker (daily use, ≥ 100 cigarettes in entire life) aged 25-65 with interest in trying an EC
• • Willing to abstain from all nicotine, tobacco products, and marijuana for at least 12 hours before study visits
• • Read and speak English
• Exclusion Criteria:
• • Currently attempting to quit nicotine or tobacco products
• • Currently pregnant (will be verified with urine pregnancy test), planning to become pregnant, or breastfeeding
• • If age 21-24 years old AND use of any tobacco products other than ECs (use of \>10 cigarettes in entire life; use of \>10 traditional cigars, cigarillos, or filtered cigars in entire life; use of smokeless tobacco products \>10 times in entire life; or hookah in the last 30 days).
• • Self-reported diagnosis of lung disease including asthma, cystic fibrosis, or chronic obstructive pulmonary disease
• • New or unstable cardiovascular disease diagnosed within the past 3 months
• • Use of medications that are inducers of CYP2A6 enzyme such as rifampicin, dexamethasone, phenobarbital, and other anti-convulsion drugs