Mobile Health (M-health) Intervention to Reduce the Epigenetic Signature in Metabolic Syndrome (MetS)

Launched by AGA KHAN UNIVERSITY · Jun 3, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how lifestyle changes can help improve body composition and reduce certain genetic markers in people with metabolic syndrome, which often includes conditions like obesity and high blood pressure. The main question is whether making healthier choices in diet and activity can lower body fat percentage and affect gene activity related to metabolism. Participants will take surveys, undergo blood tests, and receive body composition measurements at the beginning of the study, and again at 6 months and 12 months. They will also keep track of their food, physical activity, and use of a mobile health application designed to support their lifestyle changes.

To join this study, participants should be between 18 to 65 years old, have a stable body weight for the past six months, and meet specific health criteria related to waist size, cholesterol levels, blood pressure, or blood sugar levels. They must also have access to a smartphone and not currently be using a fitness app. Participants can expect regular check-ins and support to help them make lasting lifestyle changes, which could improve their health and reduce the risk of serious conditions associated with metabolic syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Less than 5 kg body weight fluctuation in the 6 months prior to recruitment.
• • 2. Ideal body weight for height falling according to the South Asian Criteria as per WHO recommended i.e. Body Mass Index (BMI) of 18.5 to 22.9 kg/m2 (normal-weight) and above 23kg/m2 (overweight/ obese).
• • 3. Any one of the following characteristics "according to the modified National Cholesterol Education Program (NCEP) ATPIII guidelines i) waist circumference ii) hyper triglyceridemia (triglycerides ≥150 mg/dl) or low High density lipoprotein (HDL) cholesterol (HDL cholesterol ≤40 mg/dl for men and ≤50 mg/dl for women iii) elevated blood pressure (systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg or current use of antihypertensive drugs) iv) impaired fasting glucose (fasting plasma glucose ≥100mg/dl) v) waist circumference (90 cm in men and 80 cm in women)".
• • 4. Have access to a smart phone/mobile and not using the fitness application
• Exclusion Criteria:
• • 1. Age \<18 or above 65 year
• • 2. Pregnant women
• • 3. Individuals with other comorbidities such as cancers, hepatic and/or renal impairment, or on hormonal supplements and/or anti-inflammatory drugs etc.
• • 4. Unfit for blood testing or no smart phone available