Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue

Launched by CENTRE HOSPITALIER UNIVERSITAIRE, AMIENS · Jun 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a type of cancer called squamous cell carcinoma (SCC) of the tongue. SCC can be a very aggressive cancer, and if it isn't found early, it can be difficult to treat. The researchers want to find better ways to detect this cancer early by looking at differences in the chemical makeup of tongue tissue. They are particularly interested in using a special imaging technique called Proton Magnetic Resonance Spectroscopy (1H-MRS) to see if it can help identify changes in the tissue of patients with SCC compared to healthy individuals.

To participate in the trial, patients must be adults (over 18 years old) with a confirmed diagnosis of SCC of the tongue that hasn't started treatment yet. They need to have a tumor that is at least 15 mm in size. Healthy volunteers who have no history of cancer in the upper mouth or throat are also welcome to join. Participants can expect to undergo non-invasive imaging and may provide valuable information that could lead to better cancer detection methods. It's important to know that the study is currently recruiting participants, and they must meet specific criteria to be eligible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patients:
• • Patients from the maxillofacial surgery department of the Amiens-Picardie University Hospital treated for histologically confirmed squamous cell carcinoma of the tongue
• • Patients who have not yet been treated, either surgically or by neoadjuvant treatment
• • Patients with a tumor of minimum dimensions of 15 mm in long axis
• • Patients without contraindication to MRI
• • Patients over 18 years old
• • Patients who have provided free and informed written consent
• • Patients benefiting from a social security system
• Healthy volunteers:
• • Subjects without a history of cancer of the upper aerodigestive tract
• • Subjects without contraindication to MRI
• • Subjects over 18 years old
• • Subjects who have provided free and informed written consent
• • Subjects benefiting from a social security system
• Exclusion Criteria:
• * Patients:
• • Patients with a lingual tumor measuring less than 15 mm in long axis
• Patients and healthy volunteers:
• • Patients with other histological types of cancer, or other locations
• • Subjects with a contraindication to MRI
• • Subjects under 18 years old
• • Pregnant or breastfeeding women
• • Persons under guardianship, curators, protection of justice or deprived of liberty