Senescent Endometrial Cells in Patients with Thin Endometrial Lining

Launched by TRIO FERTILITY · Jun 3, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a condition called thin endometrial lining, which can affect women trying to conceive. Specifically, the study aims to find out if there are certain aging cells, known as senescent cells, present in the endometrial lining of women who have been using birth control pills for a long time. These cells might be linked to the problems some women face with their endometrial lining not responding to hormones like estrogen.

To participate in this study, women aged 18-39 who have a body mass index (BMI) up to 35 and have been diagnosed with Asherman's syndrome or have a thin endometrium after using oral contraceptive pills may be eligible. Participants will undergo an ultrasound to check the thickness of their endometrial lining and a small procedure to collect tissue samples from the lining. It’s important to know that women with certain health conditions or currently using hormonal birth control won’t be able to participate. This study is a valuable step in understanding issues related to fertility and may help improve treatment options in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age 18-39
• • BMI - up to 35
• • Thin endometrium after OCP use
• • Asherman's syndrome
• • Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing)
• • Women with archived endometrial biopsy samples
• Exclusion Criteria:
• • Women with systemic disease (Rheumatic disease, DM)
• • Women with coagulopathies
• • Women with active pelvic inflammatory process
• • Uterine anomalies
• • Pregnant women
• • Any hormonal contraception use or IUD