Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus") Syndrome?

Launched by UNIVERSITY OF CAMPINAS, BRAZIL · Jun 7, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a condition called resistant arterial hypertension (RAH), where blood pressure remains high despite treatment. Researchers are trying to understand the complex factors that contribute to this condition, including how the nervous system, hormones, and immune responses interact. The goal is to learn more about the underlying causes of RAH and how it affects individuals differently, which could improve treatment options in the future.

To participate, individuals must be at least 35 years old and diagnosed with resistant hypertension according to established guidelines. They should be able to communicate effectively and have been under regular care for at least six months. The study will involve a series of assessments to measure various health indicators, and participants will receive detailed instructions on what to expect. Importantly, those with certain heart or kidney conditions, or who are pregnant, will not be eligible for the trial. This research is crucial for developing better treatments for those struggling with this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • men and women over 35 years of age diagnosed with resistant arterial hypertension (RH), in accordance with the latest international and national guidelines;
• • be able to understand, verbalize and answer questions;
• • agree to participate in the study and sign the Informed Consent Form;
• • after clearly understanding it;
• • be under regular follow-up at the UNICAMP Cardiovascular Pharmacology outpatient clinic for at least six months;
• • have proven adherence to non-pharmacological and pharmacological treatment;
• • women in the reproductive phase must be using a proven effective contraceptive method.
• Exclusion Criteria:
• • clinical history or clinical symptoms of heart failure;
• • patients with dilated cardiomyopathies, valvular heart disease, pericardial disorders;
• • patients with cerebrovascular disease or peripheral arterial disease, nephropathies, liver diseases, smoking, autoimmune diseases and use of illicit substances;
• • any abnormal condition that may interfere with the results of the study or the health of the volunteer, as judged by the researcher;
• • women who are pregnant or intend to become pregnant;
• • current participation in another investigative study;
• • major depression or other relevant psychiatric disorders.