Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic Diseases
Launched by ANHUI MEDICAL UNIVERSITY · Jun 7, 2024
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
A total of 600 carriers of disease-causing mitochondrial DNA mutations will be selected as the research objects. The basic information, reproductive history, clinical and genetic diagnosis, and clinical symptoms of the carriers will be investigated by questionnaire. Biological samples such as blood, urine, oral epithelial cells, nails, some granulosa cells, trophoderm cells, embryo culture fluid, embryo biopsy fluid, and embryo trophoblast cells of the participants will be collected and the mutation loads of them will be measured. Placenta and umbilical cord blood samples of some fetuses wi...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Clinical diagnosis of mitochondrial DNA diseases
- Exclusion Criteria:
- • none
About Anhui Medical University
Anhui Medical University, a leading institution in medical education and research in China, is dedicated to advancing healthcare through innovative clinical trials and rigorous scientific inquiry. With a robust infrastructure and a commitment to ethical research practices, the university fosters collaboration among multidisciplinary teams to explore novel therapeutic interventions and improve patient outcomes. Its focus on translational medicine and public health reflects a deep commitment to addressing pressing health challenges both locally and globally. Through its clinical trial initiatives, Anhui Medical University aims to contribute significantly to the evidence base in medicine and enhance the quality of care provided to diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hefei, Anhui, China
Patients applied
Trial Officials
Dongmei Ji, Dr.
Study Chair
The First Affiliated Hospital of Anhui Medical University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported