Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)

Launched by ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL · Jun 6, 2024

Keywords

ClinConnect Summary

The EMBRACE Study is a clinical trial that aims to develop and test a new method for predicting a serious condition called malignant brain edema in patients who have suffered a large artery blockage in the brain and have undergone a specific treatment known as endovascular thrombectomy. This condition can cause dangerous swelling in the brain, and the researchers hope to identify patients at high risk for this complication early on, so they can receive better care.

To participate in the study, individuals must be at least 18 years old and have had a stroke within the last 24 hours. They should have undergone certain imaging tests that show the type of blockage, and they need to be treated within the study parameters. Participants will receive regular follow-ups for three months after their treatment. It's important to note that people with certain severe health issues or poor-quality imaging may not be eligible. This study is currently looking for volunteers and is open to all genders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • (1)Age \> 18 years old; (2)Onset of stroke to hospital admission \< 24 hours; (3)Admission with a head CT scan ruling out hemorrhage; (4)Patients undergoing CT perfusion scan before treatment; (5)Confirmation of internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion or tandem occlusion by Digital Subtraction Angiography (DSA) and subsequent EVT; (6)complete 3-months follow-up.
• Exclusion Criteria:
• • (1)Poor quality of preoperative CT perfusion imaging; (2)Posterior circulation occlusion or isolated anterior cerebral artery occlusion; (3)Presence of other severe diseases such as malignant tumors, severe organ failure, or other life-threatening conditions with an expected survival period of less than 90 days; (4)Incomplete imaging and clinical data.