Efficacy of Bovhyaluronidase Azoximer on Biofilms Destruction in the Urogenital Tract of the Patients With Recurrent Bacterial Vaginosis.

Launched by I.M. SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY · Jun 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called Bovhyaluronidase Azoximer to see if it can help destroy harmful bacteria in the urogenital tract of women who frequently experience bacterial vaginosis (BV). BV is a common condition that affects many women of reproductive age and is caused by an imbalance of bacteria in the vagina. This study aims to find out if this treatment can improve the effectiveness of current therapies and reduce the chances of BV coming back, ultimately enhancing the quality of life for women dealing with this issue.

To participate in the trial, women aged 18 to 45 with a confirmed diagnosis of bacterial vaginosis can sign up, provided they agree to the study terms. Participants will receive the study medication and will be monitored to see how well it works. It's important to note that women who are pregnant, breastfeeding, or have certain other health conditions will not be eligible for this study. By taking part, women may contribute to important research that could lead to better treatments for bacterial vaginosis in the future.

Gender

Female

Eligibility criteria

• Inclusion Criteria:
• • availability of written informed consent to participate in the study
• • age (18-45 years)
• • established clinically (Amsel criteria) and laboratory (microscopic examination and PCR diagnosis of vaginal discharge) diagnosis of bacterial vaginosis
• Exclusion Criteria:
• • patient refusal to further participate in the study
• • lack of patient adherence to treatment
• • pregnancy and lactation
• • the occurrence during the study of conditions and diseases that are included in the list of contraindications to the use of the drug being studied
• • presence of Candida albicans, diplococci, trichomanas), confirmed by microscopic examination and PCR diagnostics
• • presence of contraindications to the use of study drugs according to the instructions