Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines

Launched by MANSOURA UNIVERSITY · Jun 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of a medication called Glycyrrhizin for treating infections in the root canals of teeth. Researchers want to see how well Glycyrrhizin works compared to two commonly used treatments, calcium hydroxide and Ledermix, in reducing bacteria and inflammatory substances in patients with a condition called apical periodontitis, which is an infection at the tip of the tooth root.

To be eligible for the study, participants must have a single-rooted tooth that is infected and has damaged nerves (pulp necrosis). However, those who have been taking antibiotics in the last three months, have certain health issues, or have teeth that can’t be properly isolated during treatment won’t be able to join. If you participate, you can expect to receive one of the treatments and be monitored for changes in your infection. This trial is currently recruiting participants of all ages, so if you think you might be eligible, it could be a good opportunity to contribute to dental research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Single-rooted with pulp necrosis and apical periodontitis.
• Exclusion Criteria:
• • Receiving antibiotic treatment within the preceding 3 months.
• • Reporting systemic disease.
• • Teeth that could not be isolated with rubber dam.
• • Teeth with periodontal pockets deeper than 3 mm.