Association Between Euploid Embryo Grade and Maternal Age

Launched by INCEPTION FERTILITY RESEARCH INSTITUTE, LLC · Jun 6, 2024

Keywords

ClinConnect Summary

Objective: To study if there is an association between advanced maternal age and lower embryo grading of euploid embryos.

Hypothesis: Advanced maternal age is associated with a lower embryonic grade in euploid embryos.

Study Design: This is a retrospective cross-sectional study of euploid embryos from patients who have completed IVF with PGT-A testing at a fertility clinic in The Prelude Network (US sites only). A comparison of embryo grade between different age groups (\<35, 40+) will be done after controlling for baseline demographic characteristics.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients who have completed IVF egg retrieval with PGT-A testing at a fertility clinic in The Prelude Network (US clinics, excluding NYU)
• • PGT biopsy was conducted in 2023,
• • PGT biopsy was performed on blastocyst stage embryo,
• • PGT-A result is euploid.
• Exclusion Criteria:
• • PGT-A result is mosaic,
• • Embryos in which PGT-M was done and were found to be carriers of the mutation,
• • Embryos in which PGT-SR was done and were found to be carriers of the structural rearrangement.