The A D A G I O Study

Launched by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST · Jun 7, 2024

Keywords

ClinConnect Summary

The A D A G I O Study is a clinical trial looking at how different types of glaucoma surgery affect the eye's fluid movement in patients with open-angle glaucoma or ocular hypertension (a condition where eye pressure is higher than normal). The goal is to understand how these surgeries can help manage these conditions better.

To be eligible for this study, participants should be between 18 and 90 years old, have a diagnosis of glaucoma or ocular hypertension that requires surgery, and be willing to stop using their glaucoma eye drops for a short period during the trial. Participants will need to understand English to complete some of the tests. If you join the study, you can expect to undergo various tests and evaluations related to your eye health. This study is not yet recruiting participants, so there is no immediate action required, but it represents an important step in improving treatment options for glaucoma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Males or females between the ages of 18 and 90 (inclusive).
• • Able to understand the study and give informed consent.
• • Willing, able and available to participate in the study. If Flurophotometer test required must not have had prior cataract surgery.
• • Diagnosis of glaucoma or OHT which requires glaucoma surgery (trans-trabecular meshwork surgery with or without an implant, trans-scleral surgery with or without implant, ciliary body treatment, suprachoroidal surgery with or without implant, external non-incisional treatment). (Defined as primary or secondary glaucoma; all types of secondary glaucoma may be included. Glaucoma will be diagnosed based on abnormal visual field testing and corresponding disc changes once seen by a glaucoma specialist.)
• • It is judged clinically safe for the patient to undergo treatment washout (stop taking glaucoma drops).
• Exclusion Criteria:
• • Diagnostic criteria for inclusion not met.
• • Allergy to fluorescein.
• • It is judged as not clinically safe or patient is not willing to undergo treatment washout (stop taking glaucoma drops).
• • Current use of any investigational drug or device or current participation in an interventional clinical trial/study.
• • Participants in the study must be able to understand English to complete some of the tests so those who might not adequately understand written information or verbal explanations in English will not be included