Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jun 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether using echocardiography (a heart ultrasound) is beneficial for patients with a specific type of bloodstream infection caused by Staphylococcus aureus (SAB) who have a low risk of developing a serious heart infection called infective endocarditis (IE). Researchers have created a scoring system called the VIRSTA score, which helps determine which patients are at low risk for IE. In patients with a VIRSTA score below 3, echocardiography may not be necessary. The trial aims to see how this scoring system affects patient outcomes and whether echocardiography should still be performed in these cases.

To participate in the trial, individuals need to be at least 18 years old and hospitalized with a confirmed case of Staphylococcus aureus in their blood, but with a VIRSTA score under 3. Participants will receive care according to the trial’s guidelines, and they will be monitored to see how they respond to treatment. It’s important to note that there are some exclusions, such as those who have had previous echocardiography for their current infection or those who are pregnant. This study is not yet recruiting, but it aims to provide valuable information on the best approaches to managing SAB.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • Volunteers over 18 years of age;
• • Hospitalized with at least one blood culture positive for Staphylococcus aureus;
• • At the time of inclusion, negative control blood culture performed 48 hours after the first Staphylococcus aureus blood culture collection;
• • VIRSTA score \< 3; Exclusion criteria
• • Patient with catheter colonization without SAB, defined as positive blood cultures only through vascular access device specimen;
• • Patient referred to the hospital for the management of IE;
• • Contra indication to transthoracic echocardiography (TTE);
• • Echocardiography already performed before inclusion (TTE or TEE) for the current SAB;
• • Pregnancy;
• • Patient under guardianship or trusteeship.
• • Absence of written informed consent from the patient
• • No affiliation to social security (beneficiary or assignee)
• • Subject already involved in another interventional clinical research for which echocardiography must be done"