The Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Jun 13, 2024

Keywords

ClinConnect Summary

The HEAL trial is studying a method called acute normovolemic hemodilution (ANH) to see if it can help reduce the need for blood transfusions during surgery for bone tumors. This is important because receiving fewer blood transfusions may lead to fewer complications and shorter hospital stays for patients. In this study, researchers will look at whether using ANH along with a specific fluid management approach, called goal-directed fluid therapy, can lower the amount of blood transfused during surgery.

To participate in this trial, you need to be between 18 and 75 years old and scheduled for elective surgery to remove a bone tumor. You should also have a preoperative hemoglobin level of at least 11 g/dL, which is a measurement of the oxygen-carrying protein in your blood. However, certain conditions, like severe heart or liver issues, pregnancy, or being underweight or overweight, may prevent you from joining the study. If you choose to participate, you will receive detailed information about the study and what to expect during the procedure. This trial is currently recruiting participants, and your involvement could help improve treatment options for future patients undergoing similar surgeries.

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Eligibility criteria

• Inclusion Criteria:
• • 1. age 18 to 75 years;
• • 2. undergoing elective bone tumor resection surgery;
• • 3. preoperative hemoglobin ≥11 g/dL;
• Exclusion Criteria:
• • 1. using a tourniquet;
• • 2. palliative operation or minimally invasive surgery;
• • 3. BMI\<18.5 or \>30Kg/m\^2;
• • 4. international normalized ratio (INR) \>1.5 or platelet count \<100 × 10\^9/L;
• • 5. cardiopulmonary insufficiency;
• • 6. hepatic and renal dysfunction;
• • 7. active infectious disease;
• • 8. allergy to succinyl gelatin;
• • 9. pregnancy;
• • 10. declined participation in the study or declined blood transfusion