Packed Red Blood Cell Transfusion During Cardiac Arrest

Launched by NYU LANGONE HEALTH · Jun 14, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the use of packed red blood cell (PRBC) transfusions during cardiac arrest, a serious condition where the heart stops beating. The main goal is to see if giving these blood transfusions can help improve oxygen delivery to the brain and other vital organs during cardiopulmonary resuscitation (CPR). Researchers will also look at how this treatment affects brain oxygen levels, carbon dioxide levels in the blood, and the chances of patients surviving and recovering well after cardiac arrest.

To be eligible for this study, participants must be adults aged between 18 and 85 who have experienced a prolonged cardiac arrest in the hospital, meaning their heart and breathing stopped for at least 10 minutes. Those who cannot receive blood products or have certain medical conditions will not be included. The trial is not yet recruiting participants, but if someone qualifies, they can expect to receive the PRBC transfusion during their treatment, and researchers will monitor their recovery and health outcomes closely for up to 90 days after the event.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients, age ≥18 and \<85 years
• • Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes
• Exclusion Criteria:
• • Age \<18 years old
• • Age \> 85 years old
• • Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate)
• • Patients admitted to the hospital with a cardiac arrest arising from trauma
• • Patients who achieve return of spontaneous circulation within 10 minutes of CPR
• • Inability to start study product administration within 20 minutes of cardiac arrest onset
• • Prisoners
• • Women who are known to be pregnant
• • Patients with a history of RBC antibodies or positive antibody screen prior to enrollment in the study, unless previously cross-matched units are available for transfusion.
• • Patients with ultrasound evidence of right ventricular dilatation at time of CA
• • Patients with known prior objection to receipt of blood products.
• • Patients for whom administration of additional fluid volume is contraindicated (as determined by physician responsible for care)
• • Physician objection based on concern that intervention would interfere with patient care plan