Natural History of Depression, Bipolar Disorder and Suicide Risk

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Jun 14, 2024

Keywords

ClinConnect Summary

This clinical trial is studying mood disorders like depression and bipolar disorder, which are often hard to treat effectively. Researchers are looking to understand how these conditions affect patients and how they respond to different treatments, especially in relation to thoughts of suicide. By gathering information from people who are receiving treatment, the hope is to find better ways to predict which medications might help improve their mental health.

To participate, you need to be 18 years or older and currently receiving treatment for depression, bipolar disorder, or thoughts of suicide. You also need to be able to understand and sign a consent form for a related study. If you join, you’ll take part in weekly interviews and questionnaires about your treatment, and there are optional tests like blood draws and sleep studies. The study usually lasts around 12 weeks, but it may continue longer if your treatment goes beyond that time. This research is being conducted at the NIH Clinical Center in Bethesda, MD, and aims to improve care for individuals dealing with these challenging conditions.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• In order to be eligible to participate in this study, an individual must meet all of the following criteria:
• • Signed consent for Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers
• • Age 18 years or older
• • Able to provide informed consent
• • Able to read and write English
• EXCLUSION CRITERIA:
• • Unstable medical conditions in the opinion of the investigator that would preclude participation in outpatient or inpatient treatment.
• • Pregnancy
• • A current NIMH employee/staff or their immediate family member
• • Participation in the Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers, as a healthy volunteer.
• • Participants with a history of DSM-IV substance or alcohol abuse or dependence, or DSM-5 substance use disorder (except for caffeine, nicotine, or cannabis), or moderate to severe alcohol use disorder, within the preceding three months. In addition, participants who are currently using drugs (except for caffeine, nicotine, or cannabis) must not have used illicit substances or known drugs of abuse in the two weeks prior to consent and must have a negative drug urine test (except for prescribed benzodiazepines or stimulants) prior to enrolling in the study. Cannabis use is exclusionary if the use is daily, or if participants are unable to abstain during the study, or if function of daily life is impaired by use as determined by a clinician