Dobutamine for Management of Surgical Patients with Septic Shock

Launched by FIRST AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY · Jun 11, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called dobutamine for patients who are undergoing surgery and experiencing a serious condition known as septic shock. Septic shock happens when an infection leads to extremely low blood pressure that doesn't improve with fluids, and it can affect how the heart functions. The researchers want to see if giving dobutamine can help improve the health of these patients during and after surgery, especially since general anesthesia can sometimes worsen heart problems.

To participate, patients must be at least 18 years old and have septic shock while undergoing surgery that lasts more than one hour. However, some people cannot join the trial, including those who are pregnant, have certain heart conditions, or have recently taken specific heart medications. If eligible, participants will receive treatment and be closely monitored to see how dobutamine affects their recovery. This trial is currently recruiting patients, and it's an important step in understanding how to better manage septic shock in surgical settings.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with 18 years or older
• • 2. Sugery patients with septic shock and the duration of opration is more than 1 hour
• Exclusion Criteria:
• • 1. Pregnancy;
• • 2. Long-term intakeβ-receptor blocker;
• • 3. patietns with dobutamine used within 72h before enrollment;
• • 4. Patients use Recombinant Human Brain Natriuretic Peptide(rhBNP), Levosimendan and Epinephrine within 72h before enrollment;
• • 5. Patients with hyperthyroidism;
• • 6. Allergy or known sensitivity to catecholamines（norepinephrine, dobutamine etc.）and genera anesthetics.
• • 7. Patients and guardians refused to participate in this intervention clinical trial.