Efficacy and Safety of Arbidol in the Treatment of Allergic Rhinitis

Launched by ZHENG LIU · Jun 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness and safety of a medication called Arbidol for treating allergic rhinitis, which is a condition that causes symptoms like sneezing, a runny nose, nasal itching, and congestion. While there are existing treatments like nasal sprays, they don't always work for everyone. The researchers hope that Arbidol can help improve these symptoms by targeting specific processes involved in allergic rhinitis.

To participate in this trial, you need to be diagnosed with allergic rhinitis and experience at least two moderate or severe symptoms. Women who are expecting or breastfeeding, as well as those with certain health conditions like severe asthma or heart problems, are not eligible to join. If you qualify and decide to participate, you'll receive information about the trial's procedures and be asked to sign a consent form. Throughout the study, you will be monitored for any side effects and will need to keep track of your symptoms and medication use. This trial is currently not recruiting participants, but it could offer new hope for those struggling with allergic rhinitis in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with allergic rhinitis (in line with the diagnostic criteria of the "Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2015, Tianjin)" formulated by the Rhinology Group of the Otolaryngology-Head and Neck Surgery Branch of the Chinese Medical Association).
• • 2. At least 2 nasal symptoms are moderate or above (referring to sneezing, runny nose, nasal itching, nasal congestion with at least 2 symptoms ≥2 points).
• • 3. Female subjects are not pregnant or lactating and have no pregnancy and lactation plans during the trial medication period.
• • 4. The subject has not participated in other clinical trials in the previous three months and agrees not to participate in other clinical trials before reaching the endpoint of this trial.
• • 5. The subject/legally authorized representative understands the purpose and procedures of the trial and voluntarily signs the informed consent form, voluntarily participates in the study and complies with the study regulations, understands and complies with the medication dosage and follow-up plan, and correctly records the scale score, the number of medications, concomitant medication and adverse event records.
• Exclusion Criteria:
• • 1. Who are allergic to Arbidol.
• • 2. Patients with abnormal liver and kidney function (ALT and AST exceed the maximum limit of normal value by 1.5 times, and Cr exceeds the upper limit of normal value).
• • 3. Patients with abnormal ECG parameters and clinically significant (PR\>220ms, QRS\>120ms, QTc\>450ms) and bradycardia.
• • 4. Patients with severe asthma or acute asthma exacerbations.
• • 5. Patients with structural heart disease, severe hypertension (blood pressure greater than 180/110mmHg), diabetes, hyperthyroidism, malignant tumors, immunocompromise, and mental illness. Patients with structural heart disease, severe hypertension (blood pressure greater than 180/110mmHg), diabetes, hyperthyroidism, malignant tumors, immunocompromise, and mental illness.
• • 6. Patients with nasal polyps, severe deviated nasal septum, sinusitis, and hypertrophic rhinitis.
• • 7. Who have participated in other clinical studies within 3 months.
• • 8. Women are pregnant or lactating, in childbearing age with positive blood pregnancy test, or have pregnancy and lactation plans during the trial medication.
• • 9. Drug abuse and alcoholism.
• • 10. Who have received allergen-specific immunotherapy within 3 years.
• • 11. Positive infectious disease screening (hepatitis B surface antigen, hepatitis C antibody, AIDS antibody and treponema pallidum antibody).
• • 12. Who should not be included if there are other reasons in the opinion of the investigator.