Multi-parametric Magnetic Resonance Imaging for the Precise Diagnosis and Quantitative Study of Liver Steatosis, Inflammation, and Fibrosis in Chronic Liver Disease.

Launched by SHENGJING HOSPITAL · Jun 12, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a new and safer way to diagnose liver damage in patients with chronic liver disease using advanced Magnetic Resonance Imaging (MRI) techniques. These techniques aim to measure how stiff the liver is, how much fat it contains, and whether there’s inflammation or scarring. The goal is to create a method that can provide accurate results without needing to perform liver biopsies, which can be risky and only sample a small part of the liver.

To participate in this trial, individuals must be between the ages of 18 and 75 and have chronic liver disease, such as viral hepatitis or alcoholic liver disease. Participants will undergo MRI scans to gather information about their liver health. It’s important to note that some people may not be eligible, particularly those with certain medical conditions, implants, or who are pregnant. This trial is currently recruiting participants, and those involved can expect a non-invasive approach to better understand their liver condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Chronic liver disease (including viral hepatitis, alcoholic hepatitis, non alcoholic steatohepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, etc..)
• • 2. Age range of 18 to 75 years old
• • 3. Accept systematic antiviral therapy or hormone or ursodesoxycholic acid or supportive liver protection therapy
• Exclusion Criteria:
• • 1. Age less than 18 years
• • 2. Unable or unwilling to give informed consent
• • 3. Contra-indications to MRI
• • 4. Electrical implants such as cardiac pacemakers or perfusion pumps
• • 5. Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
• • 6. Ferromagnetic objects such as jewelry or metal clips in clothing
• • 7. Pregnant subjects
• • 8. Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions