Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer

Launched by GENELUX CORPORATION · Jun 13, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring a new treatment approach for patients with advanced or metastatic non-small cell lung cancer (NSCLC), a type of lung cancer that has spread and is harder to treat. The study is comparing a combination of a special virus therapy (called Olvi-Vec) and chemotherapy plus an immune checkpoint inhibitor (a type of medication that helps the immune system fight cancer) to a standard treatment called docetaxel. The goal is to see if this new combination is more effective and safe for patients who have had their cancer progress after earlier treatments.

To participate, individuals must be at least 18 years old, have a confirmed diagnosis of advanced NSCLC, and have previously received specific chemotherapy treatments. They should also be in good overall health, with manageable side effects from past therapies. Participants will receive the study treatment and have regular check-ups, including scans to monitor their progress. It's important to note that not everyone will be eligible—certain health conditions or prior treatments may exclude some patients. This trial is currently recruiting, so interested individuals should talk to their doctors to see if they qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female 18 years or older.
• • ECOG (Eastern Cooperative Oncology Group) performance status of 0 or 1.
• • Have histologically or cytologically confirmed advanced or metastatic NSCLC.
• • Histologically confirmed Stage III or IV squamous or nonsquamous \[American Joint Committee on Cancer (AJCC) 8th edition\].
• • Received at least 2 cycles and maximum of 6 cycles of front-line platinum-based chemotherapy with ICI-based therapy, regardless of PD-L1 expression.
• • Reached first disease progression by radiological assessment while receiving front-line or maintenance ICI.
• • At least one measurable target tumor lesion anywhere except the brain per RECIST 1.1 by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) scan.
• • Have adequate renal, hepatic, bone marrow function as well as adequate coagulation tests \[International Normalized Ratio (INR)\] and adequate immune function by lymphocyte count.
• • Women of child-bearing potential must have a negative serum pregnancy test prior to initiating study dosing.
• • Be willing and able to comply with scheduled visits, the treatment plan, imaging and laboratory tests.
• Exclusion Criteria:
• • Active and untreated urinary tract infection, pneumonia, or other systemic infections.
• • Current symptomatic central nervous system (CNS) metastasis.
• • Any uncontrolled systemic disease, condition or comorbidity that, in the opinion of the Investigator, would interfere with evaluation of study treatment or interpretation of patient safety or study results.
• • Persistent toxicities \[Common Terminology Criteria for Adverse Events (CTCAE) Grade ≥ 3\] caused by previous anticancer therapy; alopecia and vitiligo are excluded toxicities.
• • Required the use of additional immunosuppression other than corticosteroids for the management of an adverse event or have experienced recurrence of an adverse event if re-challenged, or currently require maintenance doses of \>10 mg prednisone or equivalent per day.
• • Receiving concurrent antiviral agent active against vaccinia virus (e.g., cidofovir, vaccinia immunoglobulin, imatinib, tecovirimat, or other agents with known anti-vaccinia activities).
• • Underwent major surgery within 4 weeks, or have insufficient recovery from surgical-related trauma or wound healing, prior to the planned first dose of treatment in either Arm.
• • Have received prior virus-based gene therapy or therapy with cytolytic virus of any type.
• • Vaccination against smallpox or monkeypox within 1 year of study therapy.
• • Any non-oncology vaccine therapy used for prevention of infectious diseases, such as seasonal (influenza) vaccinations, corona virus disease (COVID) vaccination or other vaccines, within 2 weeks of the planned first dose of study drug.
• • Clinically significant skin disease as assessed by the Investigator (e.g., severe eczema, psoriasis, or any unresolved skin injury or ulcer).
• • Known hypersensitivity to carboplatin, cisplatin, paclitaxel or nab-paclitaxel, docetaxel, or any of the constituents of Olvi-Vec (i.e., gentamicin).
• • Had severe hypersensitivity (CTCAE Grade ≥ 3) to ICI and/or any of its excipients previously.
• • Dementia or altered mental status that would prohibit informed consent, and/or psychiatric illness/social situations that might interfere or limit compliance with study requirements.