Investigation of Filaggrin Gene Mutations Among Latinx Patients With Atopic Dermatitis

Launched by UNIVERSITY OF PENNSYLVANIA · Jun 17, 2024

Keywords

ClinConnect Summary

Filaggrin deficiency is considered a major target for therapy in Atopic Dermatitis (AD).43 The current status quo with regards to FLG LOF mutations as the strongest known genetic risk factor in AD stems from incomplete data as the majority of studies that have previously examined this association have been carried out in only a limited group of populations (i.e., European ancestry).30 Such partial data impedes our full understanding of genetic risk in AD and consequently has implications for disease prognosis and management. The proposed research represents an attempt to examine long-held p...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Established diagnosis of AD based on physician report of at least one-year duration
• • Self-identification as Latino/Latinx or Hispanic
• Exclusion Criteria:
• • -