Efficacy of rTMS Treatment After Spinal Cord Injury

Launched by OSLO UNIVERSITY HOSPITAL · Jun 17, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring a new treatment for improving movement in patients who have experienced spinal cord injuries. The treatment involves a method called repetitive transcranial magnetic stimulation, or rTMS, which uses magnetic fields to stimulate specific areas of the brain that control movement. The goal is to see if this approach can help people regain some motor function after their injury. If the study shows positive results, it could lead to larger trials and possibly a new standard treatment for spinal cord injury rehabilitation.

To participate in this trial, individuals must be between 18 and 80 years old and have a specific type of spinal cord injury that affects their ability to move their arms or legs. They also need to be able to give their consent and commit to the treatment schedule. Participants will receive rTMS treatments and be monitored throughout the study. However, certain conditions may exclude someone from joining, such as having a history of severe head trauma, epilepsy, or certain medical devices implanted in the body. This trial is currently recruiting, and it offers a chance to explore a promising new therapy for those impacted by spinal cord injuries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age over 18 years and less than 80 years
• • Chronic patients with an incomplete cervical and/or thoracic spinal cord injury (traumatic and non-traumatic) affecting upper and/or lower extremities (i.e., C4-T12 and classified as ASIA C or D) (Figure 138).
• • Capable and willing to provide informed consent and able to adhere to the treatment schedule
• • Patients who can be followed for the whole duration of the study
• • 6.3 Exclusion criteria
• * Contraindication to rTMS:
• • past severe head trauma
• • history of epilepsy or ongoing epilepsy
• • active cerebral tumor
• • intracranial hypertension
• • implanted ferromagnetic devices such as cardiac pacemaker and neurostimulator and cochlear implants
• • pregnancy or lactation.
• • Any clinically significant or unstable medical or psychiatric disorder
• • Other ongoing research protocol or recent past protocol within two months before the inclusion
• • History of treatment with Deep Brain Stimulation (DBS)
• • Subjects protected by law (guardianship or tutelage measure)
• • History of substance abuse (alcohol, drugs)
• • Pending litigation
• • Impossibility to understand the protocol or to fill out the forms
• • Chronic use of sedative medication
• • Participation in another clinical trial evaluating spinal cord injury