Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning

Launched by MANSOURA UNIVERSITY HOSPITAL · Jun 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a specific measurement called the diaphragmatic thickening fraction, which can be seen using an ultrasound, can help predict if patients will be successfully taken off mechanical ventilation. Mechanical ventilation is a method used to help patients breathe when they are unable to do so on their own, often due to severe respiratory problems. The researchers hope that by measuring how well the diaphragm (the main muscle used for breathing) thickens during breathing, they can better determine which patients are ready to stop using the ventilator.

To participate in this trial, individuals must be adults over 18 years old who are currently on mechanical ventilation due to serious breathing issues. However, some people won't be eligible, such as those under 18, pregnant women, or those with certain medical conditions that could interfere with the ultrasound or affect their diaphragm's function. If someone qualifies and decides to join, they can expect to undergo ultrasound exams to measure their diaphragm's function during the study. This research aims to improve the process of safely weaning patients off mechanical ventilation, which can be a critical step in their recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients \>18 years old, who are in need for mechanical ventilation as: Life threatening hypoxia, Respiratory rate \> 30 breath/min, Disturbed conscious level.
• Exclusion Criteria:
• • Age \<18 years.
• • Pregnancy
• • Surgical incisions likely to interfere with ultrasound examination.
• • Hepato-splenomegaly, Ascites
• • Neuromuscular disease as Myasthenia gravis, kypho-scoliosis
• • Diaphragmatic Paralysis (paralyzed diaphragm exhibiting abnormal paradoxical movement, i.e., moving in a cranial direction during inspiration