UFPTI 2403-PR12: Real-Time Volumetric Ionizing Radiation Acoustic Imaging for In-vivo Proton Treatment Monitoring in Pencil-Beam Scanning

Launched by UNIVERSITY OF FLORIDA · Jun 18, 2024

Keywords

ClinConnect Summary

This clinical trial, called UFPTI 2403-PR12, is studying a new way to monitor proton radiation treatment for men with prostate cancer. The goal is to see how effective a technology called ionizing-radiation photo acoustic imaging (iRAI) is during treatment. This imaging technique helps doctors see how the treatment is working in real-time, which could improve care for patients.

To be eligible for this trial, participants must be male, aged between 65 and 74, and diagnosed with prostate cancer that hasn't spread to nearby lymph nodes. They also need to weigh less than 350 pounds and meet certain size requirements for the treatment area. If chosen to participate, men can expect a non-invasive experience where a water bag is placed on their skin during the imaging process. The trial is currently recruiting participants, and it's important for potential volunteers to understand what the study involves and to be comfortable with the procedures.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Disease: Prostate cancer
• * Treatment site:
• • Prostate or prostate and seminal vesicle
• • No regional lymph node is involved
• • Patient's body weight: Patient's body weight is less than 350 lbs to consider the total weight limit that the ProteusONE treatment table and the robotic arm can operate
• • Treatment volume size: maximum size less than 15 x 15 cm in a cross-section and a thickness less than 20 cm to consider 2D transducer matrix size
• • Provision to sign the consent form and understand the non-invasiveness of iRAI
• • Patient agreement on tolerance on placing a water bag to acquire iRAI during treatment
• • Treatment modality: Proton radiation therapy with UFHPTI's ProteusONE gantry using PBS
• Exclusion Criteria:
• • A patient who would not be tolerable or will feel nervous about being touched on the skin with a water bag
• • A patient with a significant medical implant or hardware in the treatment area