TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System

Launched by TONGJI HOSPITAL · Jun 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging method called PET/MRI to help doctors better understand and detect inflammation in the brain and spinal cord, which can happen due to various conditions like stroke, autoimmune diseases, and multiple sclerosis. The goal is to see if a special radioactive substance called 18F-DPA-714 can help visualize activated immune cells in the central nervous system, which could lead to earlier diagnosis and better treatment options for patients with these diseases.

To participate in the study, individuals aged 65 to 74 who have been diagnosed with conditions like ischemic stroke or multiple sclerosis may be eligible. However, people with certain issues, such as claustrophobia, metal implants, or kidney problems, won't be able to join. Those who take part can expect to undergo imaging tests that will help researchers gather information about inflammation in their nervous system. This trial is currently recruiting participants and hopes to improve how central nervous system diseases are diagnosed and treated in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Clinical diagnosis of ischemic stroke, autoimmune ecephalitis, Neuromyelitis optica spectrum disorders, or multiple sclerosis, etc.al
• Exclusion Criteria:
• • Claustrophobia
• • Metal Implants
• • Pregancy
• • Breast-feeding
• • Renal insufficiency (GFR \< 60 mL/min/1.73m2)
• • Allergy or other contraindication to gadolinium-based MR contrast agent