Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent
Launched by NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (NASA) · Jun 20, 2024
Trial Information
Current as of August 20, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, called Lunar OI, is exploring how men and women respond differently to changes in gravity, particularly when tilted at different angles. It looks at a condition called orthostatic intolerance, which is when a person feels dizzy or faint after standing up quickly or being tilted. The study aims to find out if wearing a special compression garment can help improve how well people tolerate these tilt angles, especially in situations that mimic the experiences of astronauts during Moon landings or launches.
To be eligible for this trial, participants need to be healthy individuals aged between 9 and 20 years. They must pass a physical screening and cannot have certain medical conditions like kidney disease or diabetes. During the study, participants will undergo tilt tests while wearing the compression garment and will be given a medication that reduces blood fluid levels, similar to what astronauts might experience. This trial is currently recruiting participants and aims to better understand how sex affects tolerance to changes in gravity, which could be important for future space travel.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • • Pass a test subject screening facility modified Air Force Class III physical
- Exclusion Criteria:
- • Known allergy to furosemide or sulfa drugs
- • Currently taking drugs or medications known to adversely interact with furosemide, including but not limited to aspirin, NSAIDs, antibiotics, or immunosuppressant drugs
- • Systemic diseases or current medications known to influence the cardiovascular system
- • Renal disease
- • Type II Diabetes
- • Pregnant participants will be excluded (a urine pregnancy screen will be made available).
About National Aeronautics And Space Administration (Nasa)
The National Aeronautics and Space Administration (NASA) is a leading U.S. government agency dedicated to the exploration of space and the advancement of aeronautics. With a mission to drive innovation and scientific discovery, NASA conducts groundbreaking research that extends to various fields, including human health and performance in space environments. By sponsoring clinical trials, NASA aims to understand the physiological and psychological effects of space travel on astronauts, ensuring their safety and well-being during long-duration missions. Through collaboration with scientific communities and institutions, NASA harnesses cutting-edge technology and expertise to address complex health challenges inherent in space exploration, ultimately contributing to both space science and terrestrial health advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Houston, Texas, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported