Cardiac Amyloidosis Discovery Trial

Launched by PIERRE ELIAS · Jun 17, 2024

Keywords

ClinConnect Summary

The Cardiac Amyloidosis Discovery Trial is a study designed to find out how well a new computer program can help identify patients who may have a serious heart condition called cardiac amyloidosis, specifically a type known as transthyretin cardiac amyloidosis (ATTR-CA). This condition can lead to heart failure and is often missed because its signs can be subtle. Through this trial, researchers at NewYork-Presbyterian Hospital will use this program to analyze heart tests and medical information to create a list of patients who might be at risk for having undiagnosed cardiac amyloidosis. Those identified will then be invited for additional testing to confirm the diagnosis.

To participate in this trial, you need to be at least 50 years old and have certain heart tests, like an ECG and echocardiogram, done within the last five years. The program will select individuals who it predicts are likely to have cardiac amyloidosis. However, people with certain conditions, such as types of amyloidosis unrelated to the heart or serious illnesses that limit their survival, cannot join. If you participate, you may help doctors understand this condition better and improve how patients are diagnosed in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • High predicted probability of having cardiac amyloidosis as determined by deep learning model.
• • Age ≥ 50 years.
• • Electronically stored ECG and echocardiogram within 5 years of study start date.
• • Ability for the patient or health care proxy to understand and sign the informed consent after the study has been explained.
• Exclusion Criteria:
• • Primary amyloidosis (AL) or secondary amyloidosis (AA).
• • Prior liver or heart transplantation.
• • Active malignancy or non-amyloid disease with expected survival of less than 1 year.
• • Previous testing for cardiac amyloidosis such as amyloid nuclear scintigraphy, cardiac, or fat pad biopsy.
• • Impairment from stroke, injury or other medical disorder that precludes participation in the study.
• • Disabling dementia or other mental or behavioral disease
• • Nursing home resident.