Decoding Motor Imagery From Non-invasive Brain Recordings as a Prerequisite for Innovative Motor Rehabilitation Therapies

Launched by HOSPICES CIVILS DE LYON · Jun 17, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how we can better understand and use brain activity related to movement, specifically focusing on helping people who have had a stroke and have difficulty using their arms. Researchers are exploring how brain signals can be decoded during both actual movements and imagined movements (motor imagery). By using advanced imaging techniques, they hope to create personalized models that can improve rehabilitation therapies for stroke patients. The goal is to see if these methods can help patients regain better control of their upper limbs.

To be eligible for the study, participants must be right-handed adults over 18 years old. Healthy volunteers will be compared to stroke patients who have upper limb motor issues but are not in the acute phase of their recovery. All participants should be able to understand instructions in French and provide informed consent. Those who join the study can expect to undergo brain imaging sessions that last about two and a half hours, where their brain activity will be monitored while performing specific tasks. This research aims to pave the way for new therapies that could significantly benefit stroke survivors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Control group:
• • Healthy subjects with age\> 18, male or female.
• • Right handed (Due to the fact that unlike right-handed people, left-handed people tend to have more complicated somatotopic organization of the motor cortex, we will avoid confounding observed differences to differences attributable to anatomic factors).
• • Registered with the French healthcare system.
• • Motivated to participate in the study.
• • Normal or corrected vision.
• • Adequate knowledge of French language to be able to follow directions.
• • Subjects must be able to listen and understand the study instructions.
• • Subjects must be able to give written informed consent before participation.
• • No history of neurological or psychiatric disease.
• • No physical disability of the arms or wrists.
• • No use of drugs affecting the central nervous system or self-reported abuse of any drugs.
• Patient group :
• • Male or female stroke patients over 18 years old.
• • Stroke patients must be not be in the acute phase of stroke.
• • Right-handed.
• • Having motor disorders in at least one of the upper limbs following the stroke, possibly with moderate accompanying deficits but no cognitive deficits.
• • Entitled to a social security scheme.
• • Motivated to participate in the study.
• • Having normal or corrected vision.
• • Having a sufficient understanding of the French language to be able to follow directions.
• • Able to listen and understand study instructions.
• • Able to give their written informed consent before participating.
• Exclusion Criteria:
• * Subjects with characteristics incompatible with MEG and MRI :
• • 1. Claustrophobia.
• • Subjects with motor impairment (only applies to control group), severe traumatic brain injury.
• • Subjects with chronic stroke (applies to both groups).
• • Subjects history of skin disease or skin allergies (multiple or severe).
• * Subjects who:
• • 1. have had an MRI within 2 weeks prior to the experiment.
• • 2. have implanted materials (any dental apparatus containing metal including or root canals or any metallic object, pacemaker, cochlear implanted in the body).
• • Subjects working with metals in their professional lives.
• • Pregnant or lactating women Pregnant or lactating women (check with a urinary test).
• • Subjects who are not able to tolerate sitting for longer than 2 hours (the estimated length of an experimental session is about 2h30mins).
• • Subjects with alcohol dependence (no consumption of alcohol or drugs at least 24 hours prior to the day of experiments).
• • Subjects currently taking a medication that may have a strong effect on MEG or EEG recordings (e.g., antidepressants, stimulant medication, etc).
• • Subjects who, in the opinion of the investigator, are not able or willing to comply with the protocol.
• • Persons under guardianship or curatorship.
• • Persons in emergency situations who cannot give their consent.
• • Subjects under 18 years of age.
• • Subjects under legal protection measures.
• • Volunteers with contraindications to MEG examination
• • Pacemaker.
• • Implanted pump including insulin pump.
• • Neurostimulator.
• • Cochlear implants or other hearing aids.
• • Metal prosthesis.
• • Intracerebral / surgical aneurysm clips.
• • Ocular or cerebral ferromagnetic foreign bodies in the upper body.
• • Neurosurgical ventriculoperitoneal shunt valves.