Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults

Launched by CENTRE HOSPITALIER RÉGIONAL METZ-THIONVILLE · Jun 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how glucose is distributed in the body during the first four days after a severe burn injury. Researchers want to understand how the amount of glucose in the bloodstream changes over time in patients who have suffered significant burns, which can help improve treatment for these individuals in intensive care.

To participate in this study, patients must be at least 18 years old and have burns covering at least 30% of their body, caused by heat. They must also be treated at the CHR Metz-Thionville burn center within eight hours after the injury. Participants will be closely monitored, and their glucose levels will be measured regularly. It's important to note that certain patients, such as those with diabetes or serious medical conditions requiring specific treatments, are not eligible to join. This study aims to gather valuable information that could improve care for future burn patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients over 18 years of age
• • Patients hospitalized with burns of at least 30% of body surface area
• • By a thermal mechanism
• • At the CHR Metz-Thionville burn center
• • managed within the 8 hours post-burn
• • Patient affiliated to a social security scheme
• • Written consent obtained from the patient (or from the trusted person, family or relatives if the patient is unable to sign/express consent) or emergency inclusion if the patient is unable to express consent and neither the trusted support person nor any member of the family or relatives is present at the time of inclusion.
• Exclusion Criteria:
• • Diabetic patients on insulin
• • Patient with a CONTRAINDICATION to GLUCOSE 30% PROAMP, solution for injection
• • Patients with pre-hospital cardiac arrest
• • extra corporeal circulation patient: Extra Corporeal Membranous Oxygenation (ECMO) or Extra Corporeal Life Support (ECLS) or CRRT (Continuous Renal Replacement Therapy)
• • patient without a central venous line or arterial catheter
• • Patient moribund or immediately subject to therapeutic limitation
• • Impossibility of trans-pulmonary thermodilution monitoring (vascular access difficulties)
• • Pregnant, parturient or breast-feeding women
• • Patient under guardianship, curatorship or safeguard of justice
• • Cognitive impairment or language barrier