Clinical Multicenter Randomized Controlled Study of Non-invasive Brain Oscillation Modulation in the Treatment of AD-MCI Patients

Launched by XUANWU HOSPITAL, BEIJING · Jun 17, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment for patients with mild cognitive impairment due to Alzheimer's disease, known as AD-MCI. The researchers will use a method called transcranial electrical stimulation, which is a non-invasive technique that gently stimulates the brain to see if it can help improve memory and cognitive function. The goal is to determine how effective this treatment is and to understand how it works.

To participate in this study, individuals need to be between the ages of 50 and 85 and have a specific level of cognitive impairment, measured by standard tests. However, those with certain medical conditions, such as a history of stroke or severe neurological issues, will not be eligible. Participants can expect to be part of a study that aims to find better ways to treat AD-MCI, and they will be closely monitored throughout the research process. Importantly, this trial is not yet recruiting patients, so interested individuals will need to wait until the study begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female AD-MCI patients between the ages of 50-85; The psychological evaluation was in accordance with MMSE score of 18-30 (including 18 and 30) and CDR score of 0.5.
• • Can cooperate to complete clinical research.
• Exclusion Criteria:
• • There is a definite history of cerebrovascular stroke, and there are definite symptoms or signs of neurological deficit at the time of onset, and there are corresponding responsible lesions left by neuroimaging.
• • Those who have a history of alcoholism, or drug addiction, or neurological diseases such as brain trauma, epilepsy, encephalitis, normal intracranial pressure hydrocephalus, etc. that can cause cognitive impairment.
• • Suffering from systemic diseases that may lead to cognitive impairment (such as liver and kidney insufficiency, endocrine diseases, vitamin deficiency).
• • Have a history of using antipsychotics for more than five years before diagnosis.
• • There are contraindications for head MRI examination.