Dexamethasone Vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty

Launched by POZNAN UNIVERSITY OF MEDICAL SCIENCES · Jun 17, 2024

Keywords

ClinConnect Summary

This clinical trial is comparing two medications, dexamethasone and dexmedetomidine, to see which one helps improve pain management after knee surgery, specifically knee arthroplasty (a surgery to replace the knee joint). The goal is to determine which medication can prolong the effectiveness of a specific type of nerve block called an erector spinal plane block, which is used to relieve pain after surgery.

To participate in this study, individuals must be at least 18 years old and planning to undergo knee replacement surgery. They should be in good general health, without serious health conditions that could complicate their participation. Those with a history of opioid abuse, certain infections, or other significant health issues may not be eligible. Participants can expect to receive either dexamethasone or dexmedetomidine and will be monitored for how well these medications help manage their pain after surgery. This trial is currently recruiting participants, and it aims to find the best approach to improve recovery and comfort following knee surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients undergoing primary hip arthroplasty
• • aged \>18 years and \<100 years
• • ASA physical status 1, 2 or 3.
• Exclusion Criteria:
• • if they refused to participate,
• • had a history of opioid abuse,
• • had an infection of the site of needle puncture,
• • were less than 18 years of age,
• • were postponed as having ASA 4 or 5,
• • had an allergy to any of the drugs used in the study,
• • renal failure (estimated glomerular filtration rate \<15ml/min/1.73m2),
• • liver failure,
• • known or suspected coagulopathy,
• • pre-existing anatomical or neurological disorders in the lower extremities,
• • intellectual disability with problems in pain evaluation,
• • severe psychiatric illness.