EXercise Enhancement After RadioTherapy for Bone Metastases
Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Jun 17, 2024
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This study investigates the potential benefits of exercise therapy for patients with bone metastases, a common and often painful complication of cancer. The study aims to determine whether a structured exercise program, in combination with standard of care cancer treatment, can improve physical function, quality of life, and overall well-being for patients undergoing palliative radiotherapy.
Participants will complete a 8-week supervised exercise program that is tailored to their individual needs and abilities. The exercises, guided by certified professionals, will focus on improving stren...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age 18 or older.
- • KPS ≥70
- • Histologically confirmed cancer and radiologically documented NSBM metastases. Spine metastases are allowed if they do not meet the exclusion criteria below.
- • At least one painful NSBM treated with palliative radiotherapy.
- • Independent with ambulation and transfers. Ambulatory aids are permitted.
- • Life expectancy of at least 6 months
- Exclusion Criteria:
- * Any untreated metastatic disease that may preclude safely performing physical exercise including:
- • History of leptomeningeal disease
- • Active (untreated/progressive) malignant spinal cord or cauda equina compression
- • Bilsky 2 or 3
- • Neurological compromise secondary to CNS involvement
- • Symptomatic brain metastases prohibiting exercise due to neurological compromise
- • High risk of instability of any boney lesion(s) that may require orthopedic intervention
- • SINS score \> 7
- • Mirels score \> 6
About University Health Network, Toronto
University Health Network (UHN), based in Toronto, is a leading academic health sciences center dedicated to advancing patient care through innovative research and education. As a prominent sponsor of clinical trials, UHN integrates cutting-edge scientific discoveries with clinical practice, facilitating the development of new therapies and treatment modalities. With a commitment to improving health outcomes, UHN collaborates with a diverse network of researchers, healthcare professionals, and industry partners, fostering an environment that prioritizes patient safety and ethical standards in clinical research. Through its extensive resources and expertise, UHN plays a pivotal role in transforming healthcare and enhancing the quality of life for patients both locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Toronto, Ontario, Canada
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported