Prophylactic Prostatectomy for Prostate Cancer (PPPC)

Launched by ROYAL MARSDEN NHS FOUNDATION TRUST · Jun 17, 2024

Keywords

ClinConnect Summary

Prostate cancer (PrCa) is the most common cancer in people assigned male at birth in the UK, with over 50,000 new cases diagnosed and 12,000 lives lost to prostate cancer in the UK each year (Cancer Research UK, 2023). This is of particular concern for individuals of Black African and Black African Caribbean ancestry who carry a 1 in 4 risk of developing prostate cancer (compared with 1 in 6 individuals overall); for people with a family history of the disease and for people who have a genetic predisposition to prostate cancer (for example those who carry a pathogenic variant in a high-risk...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • People aged 18 and over.
• * Unaffected people (ie no previous prostate surgery) assessed to be living at higher risk of prostate cancer based on either:
• • 1. Carrying a variant in a higher risk gene (eg BRCA2) AND/OR
• • 2. Having a strong family history of prostate cancer AND/OR
• • 3. Being of Black African or Black Caribbean ancestry
• • AND/OR People who have undergone a prostatectomy for prostate cancer (as part of cancer treatment
• Exclusion criteria:
• • - People deemed unsuitable to approach by clinical team based on poor performance status or current concurrent medical condition.