Predictors of Thrombus Burden in STEMI Patients and Their Impact on Outcome

Launched by ASSIUT UNIVERSITY · Jun 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called ST-segment elevation myocardial infarction (STEMI), which is a serious type of heart attack. The researchers want to understand how certain factors in patients might predict a high level of blood clots (called thrombus burden) in their heart arteries and how this might affect their recovery after treatment. Specifically, they will look at various health markers, like inflammation levels and blood viscosity, to see if they can help identify patients who may have worse outcomes after a heart attack. Over the course of the study, which will last for 12 months, they plan to recruit at least 200 patients who have been admitted to the hospital with STEMI and are undergoing a procedure to open blocked arteries.

To be eligible for the trial, participants need to be adults who have experienced a STEMI and are receiving the necessary heart procedure. However, individuals with certain health issues, such as chronic inflammatory diseases, severe liver or kidney problems, or those using specific medications, will not be included. Participants will undergo tests to measure their health markers, and the researchers will follow their recovery for up to six months after treatment to see how these factors influence their outcomes. This study aims to provide valuable insights that could help improve care for future heart attack patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All patients admitted with STEMI undergoing PPCI will be recruited in the study and the period of data collection will be continued for 12 months. Total number that will be recruited will be at least 200 cases.
• Exclusion Criteria:
• • known chronic inflammatory disease, neoplasms or severe hepatic disease; end-stage renal disorder (estimated glomerular filtration rate \< 30 ml/min/1.73 m2); undergoing renal replacement therapy; no intracoronary lesions shown via angiography; history of cardiac valve surgery; using oral anticoagulants;