Driving Pressure-guided Positive End-expiratory Pressure to Prevent Postoperative Atelectasis in Obese Children: a Prospective, Randomized Controlled Clinical Trial

Launched by HENAN PROVINCIAL PEOPLE'S HOSPITAL · Jun 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to help prevent lung problems after surgery in obese children. Specifically, the researchers are looking at a technique called Driving Pressure-guided Positive End-expiratory Pressure (PEEP), which is a method used during anesthesia to keep the lungs open and functioning well. The goal is to see if using this technique can reduce the risk of atelectasis, a condition where parts of the lung collapse and can lead to breathing difficulties after surgery.

To participate in this study, children aged 3 to 18 years who are classified as obese according to specific health guidelines may be eligible. They should be generally healthy, with no significant lung or heart issues, and must be able to cooperate during the procedure. If they join, participants can expect to receive either the new ventilation strategy or standard care during their surgery, which is expected to last at least two hours. It's important to note that children with certain medical conditions, like severe lung problems or recent respiratory infections, cannot take part in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 3-18 years old;
• • According to the People's Republic of China health industry standard "Overweight and Obesity Screening threshold for school-age children and adolescents WS_T586-2018" defined as obesity;
• • American Society of Anesthesiologists (ASA) grades I - II;
• • Children with healthy lungs and hearts;
• • Patients with general anesthesia under tracheal intubation;
• • Clear mind and able to cooperate with the anesthesiologist to receive treatment;
• • Patients who plan to have elective surgery under general anesthesia and the estimated operation duration is ≥2 hours.
• Exclusion Criteria:
• • PEEP contraindications: (a) bronchopleural fistula; (b) hypovolemic shock; (c) right ventricular failure;
• • American Society of Anesthesiologists (ASA) grade greater than II;
• • Pulmonary dysfunction, congenital heart disease children;
• • Refusal to participate in the study and/or use personal data, preoperative intubation or ventilation of children;
• • Children with upper respiratory tract infection within 2 weeks.