Role of Aging and Individual Variation in Exercise Training Responsiveness

Launched by DUKE UNIVERSITY · Jun 21, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how aging affects the body’s ability to respond to exercise, particularly in older adults who have previously completed a structured exercise program. The study aims to understand how well these individuals can adapt to exercise and improve their physical health, especially in relation to conditions like prediabetes, heart disease, and obesity. Researchers will recruit up to 8 participants to take part in a 6-month aerobic exercise program, which includes activities like walking, cycling, or swimming.

To be eligible for this trial, participants must have previously completed the STRRIDE-PD trial and have a Body Mass Index (BMI) between 18 and 45. They should also be on stable doses of any heart or metabolic medications. However, potential participants will not qualify if they have certain health conditions, such as diabetes requiring insulin, active cancer, or serious heart issues. Those who join the study can expect to engage in a structured exercise routine while contributing to important research that could benefit older adults facing health challenges related to aging and exercise.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals who completed participation in the STRRIDE-PD trial (NCT00962962)
• • Body Mass Index (BMI) \> 18 and \< 45 kg/m2
• • Stable dose (≥1 month) of any cardiometabolic medications
• Exclusion Criteria:
• • Poor vein access
• • Current use of tobacco or any nicotine products, including e-cigarettes
• • Insulin-dependent diabetes
• • Active untreated hyper or hypothyroidism with thyroid stimulating hormone (TSH) concentrations \< 1.5 or \> 10.0 uIU/mL
• • Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
• • Current, actively treated malignancy other than dermatologic conditions
• • Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
• • Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
• • Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg
• • Unable to safely participate in an exercise program per study protocol per PI discretion
• • Planned, intentional weight loss during study