Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

Launched by MASSACHUSETTS GENERAL HOSPITAL · Jun 19, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring whether giving electronic cigarettes (ECs) to smokers who are not planning to quit can help reduce their tobacco use, especially in the context of lung cancer screening. Over four weeks, 30 participants will receive free NJOY ACE 5% nicotine ECs and will be encouraged to switch from traditional cigarettes to ECs. The study aims to understand how many people are interested in joining, how acceptable the ECs are to them, and whether their smoking habits change, as well as measuring certain substances in their body that indicate tobacco use.

To be eligible, participants must have recently completed another study, smoke at least five cigarettes a day, and be willing to switch to ECs for the trial. They also need to be comfortable attending three in-person visits at Massachusetts General Hospital and own a mobile phone. Throughout the study, participants will be monitored for changes in their cigarette consumption and other health markers. This trial is currently recruiting, and it offers an opportunity for individuals who are not ready to quit smoking to explore a potentially less harmful alternative.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants who completed the Screen Assist study (NCT03611881) and self-reported smoking cigarettes at the end of the study were asked to complete a survey to ascertain their potential interest in participating in a research study to test the effects of switching from combustible cigarettes (CC) to electronic cigarettes (EC). Individuals who expressed interest in switching to EC on that survey were screened for eligibility for this pilot study
• • Smoked ≥5 cigarettes/day in past month
• • Smoking status at study entry confirmed by breath carbon monoxide (CO) ≥ 6ppm
• • Willing to try switching from CC to EC for 4 weeks
• • Owns a mobile telephone
• • English speaking
• • Willing to travel to the Massachusetts General Hospital campus for 3 in-person visits.
• Exclusion Criteria:
• • Plans to quit smoking and has set a quit date in the next 30 days
• • Used smoking cessation treatment in the past 30 days
• • Used EC on \>2 days in the past 30 days
• • Hospitalized for acute coronary syndrome, unstable angina, congestive heart failure, stroke, pneumonia or chronic pulmonary disease/asthma exacerbation in the past 1 month
• • Not willing to abstain from smoking marijuana in the 24h before each study visit