Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil

Launched by ASSAF-HAROFEH MEDICAL CENTER · Jun 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well two different treatments, Ketalar and Dexmedetomidine, can help prevent increased sensitivity to pain after using a pain-relieving medication called Remifentanil during surgery. Remifentanil is often used because it works quickly, but some patients may feel more pain afterward, a condition known as hyperalgesia. The goal is to see which of the two treatments is more effective in reducing this problem for patients undergoing laparoscopic cholecystectomy, which is a common surgery to remove the gallbladder.

To participate in this trial, you need to be between 65 and 74 years old and scheduled for a laparoscopic cholecystectomy under general anesthesia. However, if you have certain health conditions, such as chronic pain, heart issues, or if you are taking strong pain medications regularly, you may not be eligible. Participants will receive either Ketalar or Dexmedetomidine during their treatment, and the researchers will monitor how well these options help manage pain sensitivity. If you join this study, you will be contributing to important research that could improve pain management after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Patients who are about to undergo alaparoscopic cholecystectomy under general anesthesia
• Exclusion Criteria:
• • Patients with sensitivity to the anesthetic
• • Patients with chronic pain who are in regular treatment
• • Urgent surgery
• • Patients with ischemic heart disease
• • Patients with known bradycardia
• • Patients with a pacemaker
• • Prolonged use of opiates
• • Kidney/liver function problems