Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome
Launched by TAIPEI VETERANS GENERAL HOSPITAL, TAIWAN · Jun 20, 2024
Trial Information
Current as of July 22, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how two treatments—acupuncture and a special Chinese herbal tea—can help people with Dry Eye Syndrome and Sjögren's Syndrome, which causes dryness in the eyes and mouth. Researchers have found that both treatments can improve tear production, and they want to dig deeper into how these therapies actually work. They will examine blood samples from participants and use advanced techniques to look for tiny RNA molecules and understand the immune response. This research aims to provide better insights into how these treatments can help manage these conditions.
To join the study, participants must be between 20 and 75 years old and have either Dry Eye Syndrome, Sjögren's Syndrome, or be healthy individuals without chronic diseases. Specific tests, like the Schirmer's test for Dry Eye Syndrome, will be used to determine eligibility. It's important to note that certain health conditions, like pregnancy or significant illnesses, may exclude someone from participating. If you qualify, you can expect to contribute to valuable research that could improve treatment options for these common issues.
Gender
ALL
Eligibility criteria
- • Dry eye syndrome
- • Inclusion Criteria: aged between 20 and 75 years Schirmer's test less than 10 mm/5 min
- • Exclusion Criteria: Pregnancy With eye inflammation or infectious eye disease Accepted operation of eye
- • Sjögren's syndrome
- • Inclusion Criteria: primary or secondary SS aged between 20 and 75 years fulfilled the 2002 American-European Consensus Criteria for SS (AECG) had no abnormal findings of immune, liver, kidney, or blood function evaluations.
- • Exclusion Criteria: a history of alcohol abuse, diabetes mellitus, or major life-threatening condition pregnancy or breastfeeding steroid pulse therapy within three months prior to the commencement of our study.
- • non AIDDES Healthy Controls
- • Inclusion Criteria: aged between 20 and 75 years without any Chronic disease
- • Exclusion Criteria: any Sjögren's syndrome or Dry eye syndrome.
About Taipei Veterans General Hospital, Taiwan
Taipei Veterans General Hospital, located in Taiwan, is a renowned medical institution dedicated to providing comprehensive healthcare and advancing medical research. As a prominent clinical trial sponsor, the hospital is committed to exploring innovative therapies and improving patient outcomes through rigorous scientific studies. With a multidisciplinary team of experienced researchers and clinicians, Taipei Veterans General Hospital prioritizes ethical standards and patient safety while contributing to the global medical community's knowledge base. Its state-of-the-art facilities and collaborative environment foster groundbreaking research that aims to address pressing healthcare challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Taipei, , Taiwan
Patients applied
Trial Officials
Ching-Mao Chang, M.D., Ph.D.
Principal Investigator
Taipei Veterans General Hospital, Taiwan
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported